Population Biology and Comparative Genomics of Campylobacter Species

Abstract The zoonotic pathogen Campylobacter is the leading cause for bacterial foodborne infections in humans. Campylobacters are most commonly transmitted via consumption of undercooked poultry meat or raw milk products. decreasing costs whole genome sequencing enabled large genome-based analyses evolution and population structure this pathogen, as well development novel high-throughput molecular typing methods. Here, we review evolutionary diversity two clinically relevant species; C. jejuni coli. state-of-the-art phylogenetic studies showed clustering lineages into host specialists generalists with coexisting lifestyles chicken livestock-associated hosts, separation coli isolates riparian origin (waterfowl, water) from isolated clinical farm-related samples. We will give an overview recombination between both species potential impact horizontal gene transfer on adaptation . Additionally, briefly places current knowledge other such lari , concisus upsaliensis perspective. also provide how methods multilocus sequence (MLST) MLST have been used to detect trace outbreaks along food chain.